Hier die Directive für OctoberCMS unter ISPConfig3  Nginx

location /{
try_files $uri /index.php$is_args$args;}

rewrite ^themes/.*/(layouts|pages|partials)/.*.htm /index.php break;
rewrite ^bootstrap/.*/index.php break;
rewrite ^config/.*/index.php break;
rewrite ^vendor/.*/index.php break;
rewrite ^storage/cms/.*/index.php break;
rewrite ^storage/logs/.*/index.php break;
rewrite ^storage/framework/.*/index.php break;
rewrite ^storage/temp/protected/.*/index.php break;
rewrite ^storage/app/uploads/protected/.*/index.php break;